Regulation der Genexpression in S. pneumoniae-infiziertem Lungenepithel

Literatur

• 1 Schröder N W, Morath S, Alexander C. et al . Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.  J Biol Chem. 2003;  278 15587-15 594
• 2 Opitz B, Püschel A, Schmeck B. et al . Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae.  J Biol Chem. 2004;  279 36 426-36 432
• 3 Schmeck B, Zahlten J, Moog L. et al . Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor.  J Biol Chem. 2004;  279 53 241-53 247
• 4 Schmeck B, Gross R, N'Guessan P D. et al . Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium.  Infect Immun. 2004;  72 4940-4947
• 5 Hoffmann E, Dittrich-Breiholz O, Holtmann H. et al . Multiple control of interleukin-8 gene expression.  J Leukoc Biol. 2002;  72 847-855
• 6 Chen L F, Greene W C. Shaping the nuclear action of NF-kappaB.  Nat Rev Mol Cell Biol. 2004;  5 392-401
• 7 Schmitz M L, Mattioli I, Buss H. et al . NF-kappaB: a multifaceted transcription factor regulated at several levels.  Chembiochem. 2004;  5 1348-1358
• 8 Buss H, Dorrie A, Schmitz M L. et al . Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity.  J Biol Chem. 2004;  279 49 571-49 574
• 9 Muegge K. Preparing the target for the bullet.  Nat Immunol. 2002;  3 16-17