Abstract
Synthesis of (1-acyloxyethylidene)-1,1-bisphosphonic acids, where the acyl group is decanoyl (1a ), lauroyl (1b ), palmitoyl (1c ), stearoyl (1d ) or oleoyl (1e ) have been described. Preparation of (1-oleoyloxyethylidene)-1,1-bisphosphonic acid tetramethyl ester (2 ) and its P ,P ′-dimethyl ester (disodium salt 3 and acid form 4 ) in multigram scale has also been reported. Solubility of 1e in organic solvents and water was tested.
Key words
bisphosphonate - etidronate - fatty acids - synthesis - prodrug
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