New Eremophilane-Type Sesquiterpenes from Ligularia hodgsonii

Abstract

Four new eremophilanlides (1 - 4) together with a known sesquiterpene were isolated from the roots and rhizomes of Ligularia hodgsonii. The structures of these new compounds were established as 6β-(2′-methylbutanoyloxy)-10β-acetoxy-3β,8β-dihydroxyeremophil-7(11)-en-8,12-olide (1), 6β,10β-dihydroxyeremophil-7(11)-en-8α,12-olide (2), 3β-acetoxy-6,9-dien-8-oxoeremophil-12-nor-11-ketone (3), and 3β-acetoxy-6α,8α-dihydroxyeremophil-7(11),9-dien-8,12-olide (4) by means of mass, IR and NMR spectroscopy.

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