Efficient Synthesis of α,α-Difluoro Ketones Using SelectfluorTM F-TEDA-BF4

Igor Pravst; Marko Zupan; Stojan Stavber

doi:10.1055/s-2005-918424

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Synthesis 2005(18): 3140-3146
DOI: 10.1055/s-2005-918424

PAPER

Efficient Synthesis of α,α-Difluoro Ketones Using Selectfluor^TM F-TEDA-BF₄

Igor Pravst^a, Marko Zupan^a,b, Stojan Stavber*^b
^a Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, 1000 Ljubljana, Slovenia
^b Laboratory for Organic and Bioorganic Chemistry, ‘Jozef Stefan’ Institute, Jamova 39, 1000 Ljubljana, Slovenia
e-Mail: stojan.stavber@ijs.si;

Further Information

Publication History

Received 30 May 2005
Publication Date:
06 October 2005 (online)

Abstract
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Abstract

Selective and efficient synthesis of α,α-difluoro ketones was achieved following a protocol which includes the transformation of α-methylene ketones to the corresponding n-butylimine derivatives and their further treatment with Selectfluor^TM F-TEDA-BF₄ in acetonitrile solution at 80 °C.

Key words

halogenation - fluorination - imines - ketones - α,α-difluoro ketones - Selectfluor F-TEDA-BF₄

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