Facile Synthesis of (S)-Gizzerosine - A Potent Inducer of Gizzard Erosion in Chicks - Using Successive Zinc-Mediated and Palladium-Catalyzed Coupling Reactions

Yasuharu Shimasaki; Hiromasa Kiyota; Minoru Sato; Shigefumi Kuwahara

doi:10.1055/s-2005-918447

SHORTPAPER

Facile Synthesis of (S)-Gizzerosine - A Potent Inducer of Gizzard Erosion in Chicks - Using Successive Zinc-Mediated and Palladium-Catalyzed Coupling Reactions

Yasuharu Shimasaki^a, Hiromasa Kiyota*^a, Minoru Sato^b, Shigefumi Kuwahara^a
^a Division of Bioscience & Biotechnology for Future Bioindustry, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiya, Aoba-ku, Sendai 981-8555, Japan
Fax: +81(22)7178783; e-Mail: kiyota@biochem.tohoku.ac.jp;
^b Division of Biological Resource Science, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiya, Aoba-ku, Sendai 981-8555, Japan

Abstract

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Abstract

Gizzerosine, a potent inducer of gizzard erosion in chicks, was synthesized using successive zinc-mediated and palladium-catalyzed coupling reactions as the key steps. The piperonyl moiety was used as a novel N-protecting group.

Key words

gizzerosine - gizzard erosion - chickens - total synthesis - histamine

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Referenzen

References

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