Efficient Palladium-Catalysed Enamide Synthesis from Enol Triflates and Enol Tosylates

Michael C. Willis; Gareth N. Brace; Ian P. Holmes

doi:10.1055/s-2005-918480

PAPER

Efficient Palladium-Catalysed Enamide Synthesis from Enol Triflates and Enol Tosylates

Michael C. Willis*^a, Gareth N. Brace^a, Ian P. Holmes^b
^a Department of Chemistry, University of Bath, Bath, BA2 7AY, UK
^b Discovery Research, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Fax: +44(1225)386231; e-Mail: m.c.willis@bath.ac.uk;

Abstract

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Abstract

Catalysts generated from Pd₂(dba)₃ and biphenyl ligands 4 and 7 efficiently promote the coupling of amides and carbamates with unactivated vinyl triflates and tosylates, to provide enamides in good to excellent yields.

Key words

enamides - palladium - catalysis - enol triflates - enol tosylates

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