Semin Reprod Med 2005; 23(4): 348-353
DOI: 10.1055/s-2005-923392
Copyright © 2005 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

The Process of Decision Making in Reproductive Medicine

Annika K. Ludwig1  Dr. Med. , Klaus Diedrich1  Prof.  Dr. , Michael Ludwig2  Prof.  Dr. 
  • 1Department of Gynecology and Obstetrics, University Clinic Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
  • 2Endokrinologikum Hamburg, Zentrum für Hormon- und Stoffwechselerkrankungen, Gynäkologische Endokrinologie und Reproduktionsmedizin, Hamburg, Germany
Further Information

Publication History

Publication Date:
29 November 2005 (online)

ABSTRACT

The decision-making process regarding the optimal infertility treatment strategy is influenced by several factors. In addition to the underlying cause of infertility, the process of decision making is also influenced by other factors. These factors are mainly (1) the duration of infertility, (2) patient's age, and (3) the number of previously performed treatment cycles of intrauterine insemination (IUI) or in vitro fertilization (IVF). The duration of infertility influences diagnostic steps as well as therapeutic options. With an infertility of at least 5 years the benefit of intrauterine insemination is limited and couples should be counseled to go forward with IVF. Patients age ≥ 40 years should be treated with IVF, whereas patients age ≥ 43 years should be counseled about their very limited chance to conceive even through IVF. The number of insemination cycles should be limited to four. Couples who have undergone at least six IVF cycles should be counseled to discontinue therapy. The treatment program should be as individualized as possible, with individual counseling that is adapted after each single treatment cycle.

REFERENCES

  • 1 Schröder A K, Tauchert S, Ortmann O, Diedrich K, Weiss J. Insulin resistance in patients with polycystiv ovary syndrome.  Ann Med. 2004;  36 426-439
  • 2 Steptoe P C, Edwards R G. Reimplantation of a human embryo with subsequent tubal pregnancy.  Lancet. 1976;  1(7965) 880-882
  • 3 Van Steirteghem A, Liu J, Joris H et al.. Higher success rate by intracytoplasmic sperm injection than by subzonal insemination. Report of a second series of 300 consecutive treatment cycles.  Hum Reprod. 1993;  8 1055-1060
  • 4 Devroey P, Liu J, Nagy Z et al.. Pregnancies after testicular sperm extraction and intracytoplasmic sperm injection in non-obstructive azoospermia.  Hum Reprod. 1995;  10 1457-1460
  • 5 Evers J L. Female subfertility.  Lancet. 2002;  360 151-159
  • 6 Kupka M S, Dorn C, Richter O, Felberbaum R, van der Ven H. Impact of reproductive history on in vitro fertilization and intracytoplasmatic sperm injection outcome. evidence form the German IVF Registry.  Fertil Steril. 2003;  80 508-516
  • 7 Nuojua-Huttunen S, Tomas C, Boigu R, Tuomivaara L, Martikainen H. Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome.  Hum Reprod. 1999;  14 698-703
  • 8 Tomlinson M J, Amissah-Arthur J B, Thompson K A, Kasraie J L, Bentick B. Prognostic indicators for intrauterine insemination (IUI): statistical model for IUI success.  Hum Reprod. 1996;  11 1892-1896
  • 9 Pisarska M, Carson S A, Casson P R, Tong X, Buster J E, Kieback D G. A mutated progesterone receptor allele is more prevalent in unexplained infertility.  Fertil Steril. 2003;  80 651-653
  • 10 Lass A, Croucher C, Duffy S, Dawson K, Margara R, Winston R M. One thousand initiated cycles of in vitro fertilization in women > or = 40 years of age.  Fertil Steril. 1998;  70 1030-1034
  • 11 Society for Assisted Reproductive Technology and the American Society for Reproductive Medicine . Assisted reproductive technology in the United States: 1998 results generated from the American Society for Reproductive Medicine /Society for Assisted Reproductive Technology Registry.  Fertil Steril. 2002;  77 18-31
  • 12 Pantos K, Athanasiou V, Stefanidis K, Stavrou D, Vaxevanoglou T, Chronopouplou M. Influence of advanced age on blastocyst development rate and pregnancy rate in assisted reproductive technology.  Fertil Steril. 1999;  71 1144-1146
  • 13 Dickey R P, Taylor S. LU PY, Satro B M, Rye P H, Pyrzak R. Effect of diagnosis, age, sperm quality, and number of preovulatory follicles on the outcome of multiple cycles of clomiphene citrate-intrauterine insemination.  Fertil Steril. 2002;  78 1088-1095
  • 14 Deutsches I VF. Register. D.I.R. - Deutsches IVF Register 2001.  2002; 
  • 15 Anderson A N, Wohlfahrt J, Christens P, Olsen J, Melbye M. Maternal age and fetal loss: population based linkage study.  BMJ. 2000;  320 1708-1712
  • 16 Auyeung A, Klein M E, Ratts V S, Odem R R, Williams D B. Fertility treatment in the forty and older women.  J Assist Reprod Genet. 2001;  18 638-643
  • 17 Schröder A K, Katalinic A, Diedrich K, Ludwig M. Cumulative pregnancy rates and drop-out rates in a German in-vitro fertilization program: 4102 cycles in 2130 patients.  Reprod Biomed Online. 2004;  8 600-606
  • 18 Schröder A K, Katalinic A, Diedrich K, Ludwig M. Kumulative Schwangerschaften und Therapieabbrüche bei Patientinnen 40 Jahren: 394 Zyklen bei 151 Frauen.  Geburtsh Frauenheilk. 2004;  64 723-729
  • 19 Lass A, Croucher C, Duffy S, Dawson K, Margara R, Winston R M. One thousand initiated cycles of in vitro fertilization in women > or = 40 years of age.  Fertil Steril. 1998;  70 1030-1034
  • 20 Dunson D B, Colombo B, Baird D D. Changes with age in the level and duration of fertility in the mentrual cycle.  Hum Reprod. 2002;  17 1399-1403
  • 21 Imani B, Eijkemans M J, Habbema J D, Fauser B C. Predictors of chances to conceive in ovulatory patients during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility.  J Clin Endocrinol Metab. 1999;  84 1617-1622
  • 22 Gysler M, March C M, Mishell D R, Bailey E. A decade's experience with an individulized clomiphene treatment regimen including its effect on the postcoital test.  Fertil Steril. 1982;  37 161-167
  • 23 Aboulghar M, Mansour R, Serour G I, Abdrazek A, Amin Y, Rhodes C. Controlled ovarian hyperstimulation and intrauterine insemination for treatment of unexplained infertility should be limited to a maximum of three trials.  Fertil Steril. 2001;  75 88-91
  • 24 Peterson C M, Hatasaka H H, Jones K P, Poulson A M, Carrell D T, Urry R L. Ovulation induction with gonadotropins and intrauterine insemination compared with in vitro fertilization and no therapy: a prospective, randomized, cohort study and meta-analysis.  Fertil Steril. 1994;  62 535-544
  • 25 Khalil M R, Rasmussen P E, Erb K, Laursen S B, Rex S, Westergaard H B. Intrauterine insemination with donor semen. An evaluation of prognostic factors based on a review of 1131 cycles.  Acta Obstet Gynecol Scand. 2001;  80 342-348
  • 26 Martinez A R, Bernardus R E, Vermeiden P M, Schoemaker J. Basic questions on intra-uterine insemination: an update.  Obstet Gynecol Surv. 1993;  48 811-828
  • 27 Osmanagaoglu K, Tournaye H, Camus M, Van Steirteghem A, Devroey P. Cumulative delivery rates after intracytoplasmatic sperm injection: 5-yearS follow-up of 498 patients.  Hum Reprod. 1999;  14 2651-2655
  • 28 Stolwijk A M, Wrtzels A MM, Braat D DM. Cumulative probability of achieving an ongoing pregnancy after in-vitro fertilization and intracytoplasmatic sperm injection according to a woman's age, subfertility diagnosis and primary or secondary subfertility.  Hum Reprod. 2000;  15 203-209
  • 29 Ulug U, Ben-Shlomo I, Turan E, Erden H F, Akman M A, Bahceci M. Conception rates following assisted reprodcution in poor responder patients: a retrospective study in 300 consecutive cycles.  Reprod Biomed Online. 2003;  6 439-443
  • 30 De Sutter P, Dhont M. Poor response after hormonal stimulation for in vitro fertilization is not related to ovarian aging.  Fertil Steril. 2003;  79 1294-1298
  • 31 Wood S, Rahim R, Searle T et al.. Optimal treatment for poor responders to ovarian stimulation: does in vitro insemination offer any advantages to intrauterine insemination? Hum Fertil (Camb) JID - 100888143 EDAT- 2002/02/15 10:00 MHDA- 2002/02/15 10:00 AID - huf0030020 [pii] PST - publish.  2003;  6 13-18
  • 32 Surrey E, Schoolcraft W B. Evaluating strategies for improving ovarian response of the poor responder undergoing assisted reproductive techniques.  Fertil Steril. 2000;  73 667-676
  • 33 Ludwig M, Strik D, Al-Hasani S, Diedrich K. No transfer in a planned ICSI cycle: we cannot overcome some basic rules of human reproduction.  Eur J Obstet Gynecol Reprod Biol. 1999;  87 3-11
  • 34 Jones G M, Trounson A, Lolatgis N, Wood C. Factors affecting the success of human blastocyst development and pregnancy following in vitro fertilization and embryo transfer.  Fertil Steril. 1998;  70 1022-1029
  • 35 Shulman A, Ben-Nun I, Ghetler Y, Kaneti H, Shilon M, Beyth Y. Relationship between embryo morphology and implantation rate after in vitro fertilization treatment in conception cycles.  Fertil Steril. 1993;  60 123-126
  • 36 Ludwig M. Does the addition of luteinizing hormone in ovarian stimulation protocols improve the outcome?.  Treat Endocrinol. 2003;  2 305-313
  • 37 Kolibianakis E, Zikopoulos K, Smitz J et al.. Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists.  Fertil Steril. 2004;  82 102-107
  • 38 Campana A, Sakkas D, Stalberg A, Bianchi P G, Comte I, Pache T. Intauterine insemination: evaluation of the results according to the woman's age, sperm quality, total sperm count per insemination and life table analysis.  Hum Reprod. 1996;  11 732-736
  • 39 Osmanagaoglu K, Collins J A, Kolibianakis E et al.. Spontaneous pregnancies in couples who discontinued intracytoplasmatic sperm injection treatment: a 5-years follow-up study.  Fertil Steril. 2002;  78 550-556
  • 40 Kupka M S, Sobalaa A, van der Ven H. Spontaneous conception after infertility treatment.  Reproduktionsmedizin. 2002;  18 110-115

 Dr.
Annika K Ludwig

Department of Gynecology and Obstetrics, University Clinic Schleswig-Holstein

Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

Email: A. K. Ludwig@web.de