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Synthesis 2006(2): 344-348
DOI: 10.1055/s-2005-924766
DOI: 10.1055/s-2005-924766
PAPER
© Georg Thieme Verlag Stuttgart · New York
Water-Accelerated Synthesis of Novel Bis-2,3-dihydroquinazolin-4(1H)-one Derivatives
Further Information
Received
28 June 2005
Publication Date:
21 December 2005 (online)
Publication History
Publication Date:
21 December 2005 (online)
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Abstract
Bisdihydroquinazolinones were synthesized for the first time by a novel pseudo five-component condensation of isatoic anhydride, a primary amine, and a dialdehyde in water. Several solvents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent.
Key words
multicomponent reactions - heterocycles - catalysis - bisdihydroquinazolinones - water
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