Bei der Sentinel-Lymph-Node-Diagnostik mit Technetium-99m-markierten Tracern kommt es nicht nur zu einer Strahlenexposition der beteiligten Personen in der Nuklearmedizin, die generell einer gesetzlich geregelten Strahlenüberwachung unterliegen, sondern auch des normalerweise nicht überwachten Personals des Operationsteams sowie in der Pathologie. Die Strahlenexposition aller außerhalb der Nuklearmedizin beteiligten Personen soll für gängige Indikationen wie malignes Melanom und Mammakarzinom dargestellt und daraus erforderliche Strahlenschutzmassnahmen im Rahmen geltender Strahlenschutzvorschriften abgeleitet werden. Außerdem soll anhand des noch experimentellen Ansatzes bei Kopf-Hals-Tumoren aufgezeigt werden, wie durch veränderte Grundbedingungen im Prozedere die Strahlenexposition beeinflusst wird.
Abstract
Due to radioguided sentinel lymph node detection with technetium-99m labeled radiotracers not only persons working in the nuclear medicine department who are monitored for radiation exposure as required by national law but also personnel in the operating room and in the pathology laboratories are exposed to radiation. The radiation exposure for these workers will be presented for standard diagnostic procedures in patients with breast cancer and melanoma and respective radiation protection measures according to national law will be discussed. Based on experimental settings in patients with head and neck cancers, we will also demonstrate how the radiation exposure to the personnel is affected by varying procedure conditions.
2
Veronesi U, Paganelli G, Galimberti V. et al .
Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes.
Lancet.
1997;
349
1864-1867
6
Maza S, Valencia R, Geworski L. et al .
Peritumoural versus subareolar administration of technetium-99m nanocolloid for sentinel lymph node detection in breast cancer: preliminary results of a prospective intra-individual comparative study.
Eur J Nucl Med Mol Imaging.
2003;
30
651-656
8
Cochran A J, Wen D R, Morton D L.
Management of the regional lymph nodes in patients with cutaneous malignant melanoma.
World J Surg.
1992;
16
214-221
9
Pijpers R, Collet G J, Meijer S, Hoekstra O S.
The impact of dynamic lymphoscintigraphy and gamma probe guidance on sentinel node biopsy in melanoma.
Eur J Nucl Med.
1995;
22
1238-1241
10
Vogt H, Bachter D, Buchels H K. et al .
[Sentinel lymph node detection by preoperative lymphoscintigraphy and intraoperative gamma probe guidance in malignant melanoma].
Nuklearmedizin.
1999;
38
95-100
11
Maza S, Valencia R, Geworski L. et al .
Influence of fast lymphatic drainage on metastatic spread in cutaneous malignant melanoma: a prospective feasibility study.
Eur J Nucl Med Mol Imaging.
2003;
30
538-544
12
Munz D L.
Does increased lymphatic density contribute to fast drainage and metastatic spread to sentinel lymph nodes in melanoma?.
Br J Cancer.
2004;
91
193
13
Koch W M, Choti M A, Civelek A C, Eisele D W, Saunders J R.
Gamma probe-directed biopsy of the sentinel node in oral squamous cell carcinoma.
Arch Otolaryngol Head Neck Surg.
1998;
124
455-459
14
Alex J C, Sasaki C T, Krag D N, Wenig B, Pyle P B.
Sentinel lymph node radiolocalization in head and neck squamous cell carcinoma.
Laryngoscope.
2000;
110
198-203
16
Shoaib T, Soutar D S, MacDonald D G. et al .
The accuracy of head and neck carcinoma sentinel lymph node biopsy in the clinically N0 neck.
Cancer.
2001;
91
2077-2083
17
Barzan L, Sulfaro S, Alberti F. et al .
Gamma probe accuracy in detecting the sentinel lymph node in clinically N0 squamous cell carcinoma of the head and neck.
Ann Otol Rhinol Laryngol.
2002;
111
794-798
18
Hoft S, Muhle C, Brenner W, Sprenger E, Maune S.
Fine-needle aspiration cytology of the sentinel lymph node in head and neck cancer.
J Nucl Med.
2002;
43
1585-1590
19
Nieuwenhuis E J, Castelijns J A, Pijpers R. et al .
Wait-and-see policy for the N0 neck in early-stage oral and oropharyngeal squamous cell carcinoma using ultrasonography-guided cytology: is there a role for identification of the sentinel node?.
Head Neck.
2002;
24
282-289
22
Muhle C, Brenner W, Sudmeyer M. et al .
CT-guided lymphoscintigraphy in patients with squamous cell carcinoma of the head and neck: a feasibility study.
Eur J Nucl Med Mol Imaging.
2004;
31
940-944
23
de Hullu J A, Doting E, Piers D A. et al .
Sentinel lymph node identification with technetium-99m-labeled nanocolloid in squamous cell cancer of the vulva.
J Nucl Med.
1998;
39
1381-1385
25
Sherif A, De La Torre M, Malmstrom P U, Thorn M.
Lymphatic mapping and detection of sentinel nodes in patients with bladder cancer.
J Urol.
2001;
166
812-815
26
Levenback C, Coleman R L, Burke T W. et al .
Lymphatic mapping and sentinel node identification in patients with cervix cancer undergoing radical hysterectomy and pelvic lymphadenectomy.
J Clin Oncol.
2002;
20
688-693
27
Kroon B K, Horenblas S, Estourgie S H. et al .
How to avoid false-negative dynamic sentinel node procedures in penile carcinoma.
J Urol.
2004;
171
2191-2194
28
Jeschke S, Nambirajan T, Leeb K. et al .
Detection of early lymph node metastases in prostate cancer by laparoscopic radioisotope guided sentinel lymph node dissection.
J Urol.
2005;
173
1943-1946
29
Selman T J, Luesley D M, Acheson N, Khan K S, Mann C H.
A systematic review of the accuracy of diagnostic tests for inguinal lymph node status in vulvar cancer.
Gynecol Oncol.
2005;
99
206-214
30
Roca I, Caresia A P, Gil-Moreno A. et al .
Usefulness of sentinel lymph node detection in early stages of cervical cancer.
Eur J Nucl Med Mol Imaging.
2005;
32
1210-1216
32
Miner T J, Shriver C D, Flicek P R. et al .
Guidelines for the safe use of radioactive materials during localization and resection of the sentinel lymph node.
Ann Surg Oncol.
1999;
6
75-82
34
Brenner W, Ostertag H, Peppert E. et al .
Radiation exposure to the personnel in the operating room and in the pathology due to SLN detection with 99mTc-nanocolloid in breast cancer patients.
Nuklearmedizin.
2000;
39
142-145
35
Waddington W A, Keshtgar M R, Taylor I. et al .
Radiation safety of the sentinel lymph node technique in breast cancer.
Eur J Nucl Med.
2000;
27
377-391
36
de Kanter A Y, Arends P P, Eggermont A M, Wiggers T.
Radiation protection for the sentinel node procedure in breast cancer.
Eur J Surg Oncol.
2003;
29
396-399
37
Morton R, Horton P W, Peet D J, Kissin M W.
Quantitative assessment of the radiation hazards and risks in sentinel node procedures.
Br J Radiol.
2003;
76
117-122
38 Gallowitsch H J. Lymphoscintigraphy and dosimetry. In: Munz DL (ed). The sentinel lymph node concept in oncology. Zuckschwerdt, München 2001; 57-66
39
Heidenreich P, Bares R, Brenner W. et al .
Verfahrensanweisung für die nuklearmedizinische Wächter-Lymphknoten (sentinel lymph node)-Diagnostik.
Nuklearmedizin.
2001;
40
98-101
40 .Strahlenschutzverordnung in der Fassung der Bekanntmachung vom 26. Juli 2001. (BGBl. I S. 1714). 2001
41 .Richtlinie 96/29/Euratom des Rates vom 13. Mai 1996 zur Festlegung der grundlegenden Sicherheitsnormen für den Schutz der Gesundheit der Arbeitskräfte und der Bevölkerung gegen die Gefahren durch ionisierende Strahlungen. Amtsblatt der Europäischen Gemeinschaften 39, L159. 1996
42
Sera T, Mohos G, Papos M. et al .
Sentinel node detection in malignant melanoma patients: radiation safety considerations.
Dermatol Surg.
2003;
29
141-145
43 Ammenwerth H. Strahlenexposition des Personals bei der SLN-Diagnostik mit Technetium-99m-Nanokolloid beim Malignen Melanom und bei Kopf-Hals-Tumoren. (Dissertation; Christian-Albrechts-Universität zu Kiel). Kiel 2005
Prof. Dr. med. W. Brenner
Klinik und Poliklinik für Nuklearmedizin · Universitätsklinikum Hamburg-Eppendorf