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Neuropediatrics 2006; 37(2): 67-71
DOI: 10.1055/s-2006-923980
Original Article

Georg Thieme Verlag KG Stuttgart · New York

Increased Prevalence of Glycoprotein IIb/IIIa Leu33Pro Polymorphism in Term Infants with Grade I Intracranial Haemorrhage

V. Havasi1 , K. Komlósi1 , J. Bene1 , 2 , B. Melegh1
  • 1Department of Medical Genetics and Child Development, University of Pécs, Pécs, Hungary
  • 2MTA‐PTE Clinical Genetics Research Group of Hungarian Academy of Sciences at University of Pécs, Pécs, Hungary
Further Information

Publication History

Received: June 14, 2005

Accepted after Revision: February 9, 2006

Publication Date:
14 June 2006 (online)

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Abstract

The prevalence rates of the platelet glycoprotein IIb/IIIa Leu33Pro allele (PLA2), and factor V G1691A Leiden mutation were determined in 109 appropriate for gestational age neonates with grade I intraventricular haemorrhage (IVH) and in 118 IVH-free control infants. The PLA2 allele frequency was 16.4 % in the group of full-term infants with grade I IVH, while it was 9.5 % in the relevant controls (p < 0.005); there was no difference in the PLA allele frequencies on comparing the IVH affected (8.34 %) and unaffected (9.2 %) premature infants. By contrast, the factor V Leiden allele frequency was increased only in the subgroup of premature infants with grade I IVH as compared with the appropriate premature controls (9.25 % vs. 3.34 %, respectively, p < 0.005). These data suggest that besides the factor V Leiden mutation, the PLA2 allele, which has already been suggested to have a role in neonatal alloimmune thrombocytopenia and certain subtypes of adult stroke, can have significance in the development of the events of IVH.

Key words

Increased prevalence of PLA2 - intraventricular haemorrhage - factor V Leiden

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Professor, M.D., Ph.D., D.Sc. Béla Melegh

Department of Medical Genetics and Child Development
University of Pécs

Szigeti u. 12

7624 Pécs

Hungary

Email: bela.melegh@aok.pte.hu