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Thorac Cardiovasc Surg 2006; 54(8): 544-547
DOI: 10.1055/s-2006-924414
Original Thoracic

© Georg Thieme Verlag KG Stuttgart · New York

Long-Term Results of Surgical Management of Pulmonary Metastases from Renal Cell Carcinoma

G. Marulli1 , F. Sartori1 , P. F. Bassi2 , F. dal Moro2 , A. Gino Favaretto3 , F. Rea1
  • 1Division of Thoracic Surgery, University of Padova, Padova, Italy
  • 2Division of Urology, University of Padova, Padova, Italy
  • 3Division of Oncology, University of Padova, Padova, Italy
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Publication History

Received March 3, 2006

Publication Date:
06 December 2006 (online)

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Abstract

Background: Metastatic renal cell carcinoma (RCC) has a poor prognosis and conventional treatments such as chemoradiotherapy show little efficacy. Surgical resection of pulmonary metastases from RCC is a widely accepted treatment, even if selection criteria based on prognostic factors have still not been defined. The aim of this study was to determine the long-term survival, clinical outcome and prognostic factors after surgery. Methods: Between 1988 and 2004, 59 patients underwent resection of pulmonary metastases from RCC. Univariate and multivariate analysis of prognostic factors was carried out. Results: Complete resection was achieved in 54 (91.5 %) patients. No intra- or postoperative mortality occurred, 5 (8.5 %) patients experienced postoperative complications. Overall, the 1-, 3-, and 5-year survival rates were 86.5 %, 63 % and 53 %, respectively. Age at the time of pulmonary resection was found to be the only independent factor influencing prognosis. Conclusion: Pulmonary resection of metastases from RCC is a safe and effective treatment associated with a low morbidity and mortality and with high long-term survival. The lack of other effective therapies suggests use of the surgical approach whenever possible.

Key words

Renal cell carcinoma - pulmonary metastases - nephrectomy - surgical resection

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MD Federico Rea

Division of Thoracic Surgery
University of Padua Medical School

Via Giustiniani 2

Padova

Italy

Phone: + 39 04 98 21 22 37

Fax: + 39 04 98 21 22 49

Email: federico.rea@unipd.it