Synthesis and Antibacterial Activity of Dendritic Architectures

Abstract

Synthesis of dendrimers with pentanone as core unit and m-terphenyl as surface end group has been achieved. The inhibitory activity of pentanone and its dendrimers against human pathogenic bacteria is well-documented.

Key words

pentanone - m-terphenyl - bactericidal screening - Enterococcus faecalis - Klebsiella pneumoniae - Escherichia coli

References

• 1 Cloninger MJ. Curr. Opin. Chem. Biol.  2002,  6:  742 
• 2 Boas U. Heegaard PMH. Chem. Soc. Rev.  2004,  33:  43 
• 3 Stiriba SE. Frey H. Haag R. Angew. Chem. Int. Ed.  2002,  41:  1329 
• 4 Gillies ER. Jonsson TB. Fréchet JMJ. J. Am. Chem. Soc.  2004,  126:  11936 
• 5 Nagahori N. Lee RT. Nishimura SI. ChemBioChem  2002,  3:  836 
• 6 Meijer DK. Molema G. Moolenaar D. de Zeeuw RA. Swart PJ. J. Controlled Release  1996,  39:  163 
• 7 Franssen EJF. Jansen RW. Vaalburg M. Meijer DKF. Biochem. Pharmacol.  1991,  45:  1215 
• 8 Rajakumar P. Ganesan K. Synlett  2004,  2236 
• 9 Rajakumar P. Ganesan K. Jayavelu S. Murugesan K. Synlett  2005,  1121 
• 10 Rajakumar P. Ganesan K. Tetrahedron: Asymmetry  2005,  2295 
• 11 Nemoto H. Miyata J. Yoshida M. Raku N. Fukumoto K. J. Org. Chem.  1997,  62:  7850 
• 12 Watanabe S. Iwamura M. J. Org. Chem.  1997,  62:  8616 
• 13 Deli J. Lorand T. Szabo D. Foldesi A. Pharmazie  1984,  39:  539 
• 14 Du CJF. Hart H. Ng KKD. J. Org. Chem.  1987,  52:  4311 
• 15 Rajakumar P. Kannan A. Tetrahedron Lett.  1993,  4407 
• 16 Kannappan V. Sathyamoothi P. Roop Sing D. J. Polym. Mater.  2002,  19:  65 
• 17 Sabitha G. Reddy GSKK. Bhaska Reddy K. Yadav JS. Synthesis  2004,  263 
• 18 Wang L. Sheng J. Tian H. Han J. Fan Z. Qian C. Synthesis  2004,  3060 
• 19 Freeman AW. Christoffels LAJ. Fréchet JMJ. J. Org. Chem.  2000,  65:  7612 
• 20 Rajakumar P. Ganesan K. Synth. Commun.  2004,  34:  2009