Pyridinium Ylides in the Synthesis of 2,3-Dihydrofurans

Che-Ping Chuang; An-I. Tsai

doi:10.1055/s-2006-926300

PAPER

Pyridinium Ylides in the Synthesis of 2,3-Dihydrofurans

Che-Ping Chuang*, An-I Tsai
Department of Chemistry, National Cheng Kung University, Tainan, Taiwan 70101, Taiwan
Fax: +886(6)2740552; e-Mail: cpchuang@mail.ncku.edu.tw;

Abstract

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Abstract

A new method for the synthesis of 2,3-dihydrofurans from readily available starting enones and pyridinium salts has been developed. This protocol can provide a novel and effective methodology for the preparation of 2,3-dihydrofurans in a stereoselective fashion. To increase the efficiency of this reaction the one-pot process was also developed, in which the pyridinium salts were generated in situ from corresponding halides.

Key words

pyridinium ylide - 2,3-dihydrofuran - conjugate addition - O-cyclization - one-pot process

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References

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