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Synthesis 2006(5): 803-806
DOI: 10.1055/s-2006-926334
DOI: 10.1055/s-2006-926334
PAPER
© Georg Thieme Verlag Stuttgart · New York
An Efficient Synthesis of Difluoropropargyl Bromides
Weitere Informationen
Received
12 September 2005
Publikationsdatum:
07. Februar 2006 (online)
Publikationsverlauf
Publikationsdatum:
07. Februar 2006 (online)
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Abstract
High yields of γ-alkyl, -silyl and -aryl-substituted difluoropropargyl bromides have been obtained by monitoring concentration and temperature in the reaction between CF2Br2 and γ-substituted lithium acetylide. γ-Silyl substituents afforded the corresponding α,α,α-difluorobromopropargyl alcohols in good yields via cleavage of tetrabutylammonium fluoride in the presence of an aldehyde.
Key words
alkynylation - fluorine - building block - substituent effect
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References
New address: Sumitomo Chemical Ltd. 4-2-1, Takatsukasa, Takarazuka, Hyogo 665-8555, Japan.
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