Abstract
The direct amidation of esters with 4-amino-2,2,6,6-tetramethylpiperidine was achieved by computer-controlled microwave irradiation in toluene. The microwave protocol allowed the new amides to be prepared in three hours rather than the three days required by traditional thermal methods.
Key words
microwave-assisted synthesis - HIV - amidation - CCR5 - gp120
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37 Crystallographic data (excluding structure factors) for compound 2 have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication number CCDC 286628. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax:+44 (1223)336033 or e-mail: deposit@ccdc.cam.ac.uk].
