A Simple and Direct Access to Ethylidene Malonates

Maité Sylla; Delphine Joseph; Emilie Chevallier; Cheikhou Camara; Françoise Dumas

doi:10.1055/s-2006-926344

PAPER

A Simple and Direct Access to Ethylidene Malonates

Maité Sylla, Delphine Joseph, Emilie Chevallier, Cheikhou Camara, Françoise Dumas*
Laboratoire de Synthèse de Composés d’Intérêt Biologique, BioCIS, Unité associée au CNRS, Centre d’Etudes Pharmaceutiques, Université Paris Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry Cedex, France
Fax: +33(1)46835752; e-Mail: francoise.dumas@cep.u-psud.fr;

Abstract

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Abstract

The condensation of active methylene compounds 1 with acetaldehyde was efficiently promoted by a catalytic amount of lithium bromide in the presence of acetic anhydride to give ethylidene malonates 2 in 77-97% yield.

Key words

Knoevenagel condensations - catalysis - aldol reactions - aldehydes - substituent effects

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References

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