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Synthesis 2006(8): 1279-1282
DOI: 10.1055/s-2006-926412
DOI: 10.1055/s-2006-926412
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Novel Approach to C-Trimethylsilyl-1,3-azoles
Further Information
Received
19 September 2005
Publication Date:
28 March 2006 (online)
Publication History
Publication Date:
28 March 2006 (online)

Abstract
Direct silylation of 1,3-azoles with bromotrimethylsilane in the presence of triethylamine was investigated. 5-Phenyloxazole, benzoxazole, 1-methyl-1,2,4-triazole, 2-aryl-1,3,4-oxa- and thiadiazoles were found to give the corresponding 2- or 5-trimethylsilyl derivatives.
Key words
azoles - silylation - heterocycles - electrophilic substitution - silicon
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