Abstract
(R )-Homopipecolic acid methyl ester has been prepared on a multigram scale from 3,4-dihydro-2H -pyran in five steps and 36% overall yield. The stereochemistry was introduced via an asymmetric Michael addition and a fractional crystallization.
Key words
piperidines - stereoselective synthesis - β-amino ester - Michael additions - fractional crystallization
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