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Synthesis 2006(10): 1613-1624  
DOI: 10.1055/s-2006-926460
PAPER
© Georg Thieme Verlag Stuttgart · New York

Novel Approaches to Fused Phospha-Pyrimidines

Dmitriy M. Volochnyuk*a, Svetlana A. Kovalevaa, Alexandr N. Chernegaa, Nataliya G. Chubaruka, Alexandr N. Kostyuka, Alexandr M. Pinchuka, Andrey A. Tolmachevb, Reinhard Schmutzlerc
a Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska 5, Kiev-94, 02094, Ukraine
Fax: +380(44)5373253; e-Mail: D.Volochnyuk@enamine.net;
b Research and Development Center for Chemistry and Biology, National Taras Shevchenko University, 62 Volodymyrska St., Kiev-33, 01033, Ukraine
c Institute of Inorganic and Analytical Chemistry, Technical University, Hagenring 30, 38106 Braunschweig, Germany
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Publikationsverlauf

Received 8 August 2005
Publikationsdatum:
27. April 2006 (online)

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Abstract

Simple methods for the preparation of phosphorus-containing fused pyrimidine analogues such as fused 1,5,2-diazaphosphinines from amidine derivatives of π-excessive heterocycles are described. The scope and limitations of the methodology are detailed.

Key words

phospha-pyrimidines - amidines - phosphorus(III) halides - phosphorylation - heterocyclization

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