Synthesis of a Novel Structural Variant of Imidazoquinazoline with Three-Point Diversity [1]

Abstract

An efficient strategy for the preparation of a novel structural variant of imidazoquinazolines with three-point diversity has been described. The compounds were obtained by treating benzil with o-nitrobenzaldehyde to give imidazoles, followed by reduction of the nitro group to give an aryl amine. Condensation-cyclization of the resulting intermediate with isothiocyanates in the presence of DBU for 45 minutes at room temperature furnished the title compounds in high yields and purities.

Key words

imidazoquinazoline - imidazole - DBU

1

CDRI Communication No. 6900.

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1

CDRI Communication No. 6900.

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Kundu, B. presented at IUPAC-BNP-2004, New Delhi, India, 26th-31st January 2004.