Pharmacopsychiatry 2006; 39: 68-71
DOI: 10.1055/s-2006-931498
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Cortical Microcircuits in Schizophrenia - The Dopamine Hypothesis Revisited

G. Winterer1
  • 1Department of Psychiatry, Heinrich-Heine University Hospital Duesseldorf, Germany
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Publikationsverlauf

Publikationsdatum:
01. März 2006 (online)

Strong evidence exists for disturbed functional connectivity of cortical microcircuits - particularly of prefrontal cortex. Dopamine, long implicated in antipsychotic drug effects, is crucially involved in optimizing signal-to-noise ratio of local cortical micro-circuits. This action of dopamine is achieved by means of D1- and D2-receptor-mediated effects on pyramidal and local circuit neurons, which mediate recurrent inhibition and thus contribute to the stability of cortical representations of external and internal stimuli. In schizophrenia, a diminished cortical dopamine D1/D2 activation ratio - in concert with altered GABAergic and glutamatergic transmission - appear to critically interfere with this process.

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Georg Winterer, MD, PhD

Dept. of Psychiatry

Heinrich-Heine University Hospital

Bergische Landstr. 2

D-40629 Duesseldorf

Germany

Telefon: +49-(0)211-922-3463

Fax: +49-(0)211-922-3498

eMail: georg.winterer@uni-duesseldorf.de