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DOI: 10.1055/s-2006-931569
© Georg Thieme Verlag KG Stuttgart · New York
Antimalarial Activity of Biflavonoids from Ochna integerrima
Publikationsverlauf
Received: December 1, 2005
Accepted: January 17, 2006
Publikationsdatum:
29. Mai 2006 (online)
![](https://www.thieme-connect.de/media/plantamedica/200607/lookinside/thumbnails/10.1055-s-2006-931569-1.jpg)
Abstract
During the screening of antimalarial substances, the 80 % EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 μg/mL) whereas extracts from the inner barks of O. integerrima showed no antimalarial activity. Biflavanone (1), which had not been found previously from a natural plant source, was isolated as a potent antimalarial active ingredient (IC50 value: 80 ng/mL) from the extract of the outer barks. The stereoisomer of 1 ( = compound 2) was also isolated from this plant; however, its activity was significantly lower than that of 1.
Key words
Antimalarial - Ochnaceae - Ochna integerrima Merr. - biflavanones
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Prof. Dr. Haruki Yamada
Kitasato Institute for Life Sciences
Kitasato University
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