New Polyhydroxylated Triterpenes and Anti-Inflammatory Activity of Salvia hierosolymitana

Abstract

Salvia hierosolymitana (Lamiaceae) leaves were investigated for their topical anti-inflammatory properties following a bioassay-guided fractionation. The chloroform extract showed a strong inhibition of the Croton oil-induced ear oedema in mice, comparable to that of indomethacin. Phytochemical and pharmacological investigations of this extract led to the isolation of eight anti-inflammatory polyhydroxylated triterpenes of the ursane and oleanane series. Four of them are new compounds, whose structures were elucidated by NMR and mass spectroscopy as 3β,6α,23-trihydroxyurs-12,19(29)-dien-28-oic acid, 23-(trans-p-coumaroyloxy)-3β, 6α,30-trihydroxyurs-12-en-28-oic acid, 2α,3β-dihydroxyolean-28-oic acid and 24-nor-2α,3β-dihydroxyolean-4(23),12-ene.

Key words

Salvia hierosolymitana - Lamiaceae - triterpenes - anti-inflammatory activity - Croton oil ear test

References

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