Planta Med 2006; 72(7): 640-642
DOI: 10.1055/s-2006-931575
Original Paper
Biochemistry and Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

Loading of Erythrocyte Membrane with Pentacyclic Triterpenes Inhibits Plasmodium falciparum Invasion

Hanne L. Ziegler1 , Trine Staalsø2 , Jerzy W. Jaroszewski1
  • 1Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
  • 2Centre for Medical Parasitology, Copenhagen University Hospital, Copenhagen, Denmark
Weitere Informationen

Publikationsverlauf

Received: October 8, 2005

Accepted: February 3, 2006

Publikationsdatum:
29. Mai 2006 (online)

Abstract

Lupeol and betulinic acid inhibit the proliferation of Plasmodium falciparum parasites by inhibition of the invasion of merozoites into erythrocytes. This conclusion is based on experiments employing parasite cultures synchronized by magnetic cell sorting (MACS). Identical inhibitory effects were observed upon incubation of synchronous parasite cultures in the presence of the triterpenoids, and when the parasite cultures were grown in a triterpenoid-free medium with erythrocytes preloaded with the triterpenoids.

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Prof. Jerzy W. Jaroszewski

Department of Medicinal Chemistry

The Danish University of Pharmaceutical Sciences

Universitetsparken 2

2100 Copenhagen

Denmark

Fax: +45-3530-6040

eMail: jj@dfuni.dk