Planta Med 2006; 72(7): 665-666
DOI: 10.1055/s-2006-931576
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Aeruginascin, a Trimethylammonium Analogue of Psilocybin from the Hallucinogenic Mushroom Inocybe aeruginascens

Niels Jensen1 , Jochen Gartz2 , Hartmut Laatsch1
  • 1Institute of Organic and Biomolecular Chemistry, Georg-August University Göttingen, Göttingen, Germany
  • 2Fungal Biotransformations, Leipzig, Germany
Dedicated to Dr. Albert Hofmann in honour of his 100th birthday
Weitere Informationen

Publikationsverlauf

Received: November 10, 2005

Accepted: February 3, 2006

Publikationsdatum:
28. April 2006 (online)

Abstract

The hallucinogenic mushroom Inocybe aeruginascens contains several typical Psilocybe alkaloids including psilocybin. We have now elucidated the structure of a further indole derivative named aeruginascin as the quaternary ammonium compound N,N,N-trimethyl-4-phosphoryloxytryptamine. Aeruginascin is closely related to the frog skin toxin bufotenidine (5-HTQ), a potent 5-HT3 receptor agonist, and has been found exclusively in Inocybe aeruginascens so far.

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Prof. Dr. Hartmut Laatsch

Institute of Organic and Biomolecular Chemistry

Georg-August University Göttingen

Tammannstrasse 2

37077 Göttingen

Germany

Telefon: +49-551-39-3211

Fax: +49-551-39-9660

eMail: hlaatsc@gwdg.de