Molekulare Wirkungsmechanismen von n-Butyrat

Zusammenfassung

n-Butyrat wird als Stoffwechselprodukt des anaeroben Abbaus hochpolymerer Pflanzenspeicherstoffe durch die physiologische Dickdarmflora gebildet. Die Bedeutung von n-Butyrat liegt in seiner Funktion als wichtigster Energielieferant der Kolonozyten und somit in einer stabilisierenden Wirkung auf die Kolonmukosa. Extraintestinal versorgt n-Butyrat den mitochondrialen Energiestoffwechsel von Muskel- und Hirnzellen. Daneben hat n-Butyrat eine Vielzahl wichtiger regulativer Aufgaben in den zellulären Abläufen zu übernehmen.

n-Butyrat steuert die Transkription und die posttranslationelle Modifikation von Eiweißen. Ein bedeutender Angriffspunkt sind nukleäre Transkriptionsfaktoren wie NFκB, die Einfluss auf die Entgiftung radikalischer Produkte, aber auch auf die Steuerung der Immunität über das TH₁/TH₂-Verhältnis und den gesteuerten programmierten Zelltod (Apoptose) haben. Einen entscheidenden Einfluss auf die Apoptose und die Zelldifferenzierung übt n-Butyrat durch Steuerung des Zellzyklus und der Zellteilung aus. n-Butyrat hat somit einen direkten Einfluss auf die Entstehung von Krebs und kann als natürliche Chemoprophylaxe verstanden werden. Die Diagnostik der körperlichen Versorgung mit n-Butyrat wird vorgestellt. Ebenso wird der Einsatz eines neu entwickelten funktionellen Lebensmittels zur Verbesserung der n-Butyrat-Versorgung besprochen.

Abstract

Butyric acid is a product of the anaerobic metabolism of highly polymeric plant fiber polysaccharides by the large intestine flora. Butyrate is an important energy source for colonozytes and thereby preventing the leaky-gut-syndrome. Butyrate regulates lipid metabolism, proinflammatory response, cell cycle, cell differentiation and tumorgenesis. The assessment of faecal butyric acid concentrations and their clinical relevance are discussed. The beneficial potential of optimal butyrate supply and its experimental effects on cancer is described.

Butyrat - Darmflora - Stoffwechsel - Entzündungshemmung - Chemoprophylaxe

Butyrate - intestinal flora - metabolism - antiinflammatory - chemoprevention

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