Aspirin for the Control of Platelet Activation and Prevention of Thrombosis in Essential Thrombocythemia and Polycythemia Vera: Current Insights and Rationale for Future Studies

Raffaele Landolfi; Leonardo Di Gennaro; Linda Novarese; Carlo Patrono

doi:10.1055/s-2006-939436

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2006; 32(3): 251-259
DOI: 10.1055/s-2006-939436

Aspirin for the Control of Platelet Activation and Prevention of Thrombosis in Essential Thrombocythemia and Polycythemia Vera: Current Insights and Rationale for Future Studies

Raffaele Landolfi¹ ^, ² , Leonardo Di Gennaro² , Linda Novarese² , Carlo Patrono³

¹Professor
²Institute of Internal Medicine and Geriatrics, Catholic University School of Medicine, Rome, Italy
³Department of Pharmacology, University of Rome “La Sapienza,” Rome, Italy

Abstract

ABSTRACT

Polycythemia vera and essential thrombocythemia are chronic myeloproliferative disorders characterized by a relatively benign clinical course that may be complicated by arterial and venous thromboses. A thrombotic diathesis often manifests at diagnosis or in the preclinical phase of the myeloproliferative disease. Peculiar microcirculatory disturbances such as erythromelalgia and visual and hearing symptoms also commonly occur in these patients, and are highly responsive to aspirin. In a placebo-controlled trial in relatively low-risk polycythemic subjects, low-dose aspirin recently was shown to reduce the incidence of both arterial and venous thrombosis with a limited increase of the hemorrhagic risk. Due to its favorable benefit/risk profile, low-dose aspirin should be prescribed to all patients with polycythemia vera who have no contraindication to this treatment. Future studies should assess primarily the efficacy and safety of aspirin in essential thrombocythemia, and test the possible use of more aggressive antithrombotic strategies in high-risk polycythemic patients.

KEYWORDS

Polycythemia vera - essential thrombocythemia - aspirin - platelet activation - arterial thrombosis - venous thrombosis

Full Text

References

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Raffaele LandolfiM.D.

Institute of Internal Medicine, Haemostasis Research Center, Catholic University School of Medicine

Largo Agostino Gemelli 8, 00168 Rome, Italy

Email: rlandolfi@rm.unicatt.it