Klinischer Nutzen und Perspektive - EGF-Rezeptorinhibitoren in der Tumortherapie

Zusammenfassung

Die Therapie mit molekularen, gegen den EGF-Rezeptor gerichteten Therapien ist bereits heute bei mehreren Tumorentitäten Standard. Aufgrund der Bedeutung des EGFR für die maligne Signaltransduktion und die Differenzierung bei vielen Tumorarten ist davon auszugehen, dass beide Wirkprinzipien, sowohl die extrazelluläre Blockade durch monoklonale Antikörper wie die intrazelluläre Inhibition der Tyrosinkinase des Rezeptors durch „small molecules”, bei zahlreichen weiteren Tumorentitäten einen Wirksamkeitsnachweis zeigen. Sie verbessern damit bei vielen Patienten die Prognose und geben sogar manchen die Chance auf Heilung ihres metastasierten Krankheitsstadiums.

Summary

Treatment employing molecular therapies directed against the EGF receptor has already become a standard procedure for several tumour entities. On account of the significance of the EGF receptor for the malignant signal transduction and the differentiation in a great variety of tumours we can assume that in numerous other tumour entities both active principles will be effective, namely, the extracellular blockade by monoclonal antibodies as well as the intracellular inhibition of tyrosine kinase of the receptor by "small molecules". Thus, prognosis will be improved for many patients and in quite a number of cases there is a chance that the metastasized stage of their disease may be cured.

EGF receptor - monoclonal antibodies - tyrosine kinase - tyrosine kinase inhibitors

Literatur

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1 Bowel ONcology with Cetuximab AntiboDy

2 Pan-European Trials in Alimentary Tract Cancer

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