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Dtsch Med Wochenschr 2006; 131(16): 903-906
DOI: 10.1055/s-2006-939867
DOI: 10.1055/s-2006-939867
Prinzip & Perspektive | Review article
Regenerative Medizin, Diabetologie
© Georg Thieme Verlag KG Stuttgart · New York
Inselzelltransplantation, Stammzelltherapie und regenerative Therapie bei Diabetes mellitus
Islet transplantation, stem cell transfer and regenerative therapy in diabetes mellitusFurther Information
Publication History
eingereicht: 9.1.2006
akzeptiert: 16.3.2006
Publication Date:
20 April 2006 (online)

Schlüsselwörter
Inselzelltransplantation - Stammzelltransplantation - Diabetes mellitus
Key words
islet transplantation - stem cell transfer - diabetes mellitus
Literatur
- 1 Assady S, Maor G, Amit M, Hskovitz-Eldor J, Skorecki K L, Tzuckerman M. Insulin production by human embryonic stem cells. Diabetes. 2001; 50 1691-1697
- 2 Biason-Lauber A, Boehm B, Lang-Muritano M, Ganthier B R, Brun T, Wollheim C B, Schoenle E J. Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia. 2005; 48 900-905
- 3 Bonner-Weir S, Taneja M, Weir G C, Tatarkiewicz K, Song K H, Sharma A, OŽNeil J J. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA. 2000; 97 7999-8004
- 4 Brendel M D, Eckhard M, Brandhorst D, Brandhorst H, Winter D, Jaeger C, Jahr H, Ziegler A, Iken M, Shen H, Weimer R, Rau W, Padberg W, Bretzel R G. Inselzelltransplantation - aktueller Stand und Perspektiven. Diab Stoffw. 2003; 12 239-251
- 5 Bretzel R G, Brandhorst D, Brandhorst H, Eckhard M, Ernst W, Friemann S, Rau W, Weimar B, Rauber K, Hering B J, Brendel M D. Improved survival of intraportal pancreatic islet cell allografts in patients with type-1 diabetes mellitus by refined peritransplant management. J Mol Med. 1999; 77 140-143
- 6 Bretzel R G, Browatzki C C, Schultz A, Brandhorst H, Klitscher D, Bollen C C, Raptis G, Friemann S, Ernst W, Rau W S, Hering B J. Clinical islet transplantation in diabetes mellitus - report of the International Islet Transplant Registry and the Giessen Center experience. Diab Stoffw. 1993; 2 378-390
- 7 Bretzel R G, Richardt M, Menden A, Federlin K. Pankreas-B-Zellregeneration nach Inseltransplantation beim experimentellen Diabetes mellitus. Verh Dtsch Ges Inn Med. 1984; 90 1471-1477
- 8 Dor Y, Brown J, Martinez O J, Melton D A. Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004; 429 41-46
- 9 Jahr H, Wagner S, Brendel M, Bretzel R G. Gastrin-induced insulin production in hepatocyte G2 cells. Diabetologia. 2005; (suppl 1) 48 A153
- 10 Ju Q, Edelstein D, Brendel M D, Brandhorst D, Brandhorst H, Bretzel R G, Brownlee M. Transduction of non-dividing adult human pancreatic beta-cells by an integrating lentiviral vector. Diabetologia. 1998; 41 736-739
- 11 Kodama S, Kuhtreiber W, Fujimura S, Dale E A, Faustman D L. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science. 2003; 302 1223-1227
- 12 Narushima M, Kobayashi N M, Okitsu T, Tanaka Y, Li S -A, Chen Y, Miki A, Tanaka K, Nakaji S, Takei K, Gutierrez A S, Rivas-Carrillo J D, Navarro-Alvarez N, Jun H -S, Westerman K A, Noguchi H, Lakey J RT, Leboulch P, Tanaka N, Yoon J -W. A human β-cell line for transplantation therapy to control type 1 diabetes. Nat Biotech. 2005; 23 1274-1282
- 13 Raeder H, Johansson S, Holm P I, Haldorsen I S, Mas E, Sbarra V, Nermoen I, Eide S A, Grevle L, Bjorkhaug L, Sagen J V, Aksnes L, Sovik O, Lombardo D, Molven A, Njolstad P R. Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nat Genet. 2006; 38 54-62
- 14 Ruhnke M, Ungefroren H, Nussler A, Martin F, Brulport M, Schormann W, Hengstler J G, Klapper W, Ulrichs K, Hutchinson J A, Soria B, Parwaresch R M, Heeckt P, Kremer B, Fändrich F. Differentiation of in vitro - modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells. Gastroenterology. 2005; 128 1774-1786
- 15 Ryan E A, Paty B W, Senior P A, Bigam D, Alfadhli E, Kneteman N M, Lakey J R, Shapiro A M. Five-year follow-up after clinical islet transplantation. Diabetes. 2005; 54 2060-2069
- 16 Shapiro A JM, Lakey J RT, Ryan E A, Korbutt G S, Toth E, Warnock G L, Kneteman N M, Rajotte R V. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000; 323 230-238
- 17 Zhang Y -Q, Kritzik M, Sarvetnick N. Identification and expansion of pancreatic stem/progenitor cells. J Cell Mol Med. 2005; 9 331-344
Prof. Dr. Reinhard G. Bretzel
Medizinische Klinik und Poliklinik III, Universitätsklinikum Gießen und Marburg GmbH, Standort Gießen
Rodthohl 6
35392 Gießen
Phone: 0641/9942750/-42840
Fax: 0641/9942759/-42849
Email: Reinhard.Bretzel@uniklinikum-giessen.de