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Dtsch Med Wochenschr 2006; 131(18): 1031-1034
DOI: 10.1055/s-2006-939891
DOI: 10.1055/s-2006-939891
Arzneimittel & Pharmakotherapie | Review article
Pneumologie© Georg Thieme Verlag Stuttgart · New York
Bosentan - Neues Standbein der Therapie der pulmonalen Hypertonie?
Bosentan: a new pillar in the treatment of pulmonary hypertension?Weitere Informationen
Publikationsverlauf
eingereicht: 14.9.2005
akzeptiert: 12.1.2006
Publikationsdatum:
03. Mai 2006 (online)

Schlüsselwörter
Bosentan - pulmonal-arterielle Hypertonie
Key words
Bosentan - pulmonary hypertension
Literatur
- 1
McLaughlin V V, Rich S.
Pulmonary hypertension.
Curr Probl Cardiol.
2004;
29
575-634
MissingFormLabel
- 2
Galie N, Manes A, Uguccioni L. et al .
Primary pulmonary hypertension: insights into pathogenesis from epidemiology.
Chest.
1998;
114
184S-194S
(3 Suppl)
MissingFormLabel
- 3
D’Alonzo G E, Barst R J, Ayres S M. et al .
Survival in patients with primary pulmonary hypertension. Results from a national
prospective registry.
Ann Intern Med.
1991;
115
343-349
MissingFormLabel
- 4
McLaughlin V V, Shillington A, Rich S.
Survival in primary pulmonary hypertension: the impact of epoprostenol therapy.
Circulation.
2002;
106
1477-1482
MissingFormLabel
- 5
Humbert M, Sitbon O, Simonneau G.
Treatment of pulmonary arterial hypertension.
N Engl J Med.
2004;
351
1425-1436
MissingFormLabel
- 6
Badesch D B, Abman S H, Ahearn G S. et al .
Medical therapy for pulmonary arterial hypertension: ACCP evidence-based clinical
practice guidelines.
Chest.
2004;
126
35S-62S
(Suppl 1)
MissingFormLabel
- 7
Russell F D, Davenport A P.
Secretory pathways in endothelin synthesis.
Br J Pharmacol.
1999;
126
391-398
MissingFormLabel
- 8
Dupuis J, Stewart D J, Cernacek P, Gosselin G.
Human pulmonary circulation is an important site for both clearance and production
of endothelin-1.
Circulation.
1996;
94
1578-1584
MissingFormLabel
- 9
McCulloch K M, MacLean M R.
Endothelin B receptor-mediated contraction of human and rat pulmonary resistance arteries
and the effect of pulmonary hypertension on endothelin responses in the rat.
J Cardiovasc Pharmacol.
1995;
26
S169-176
(Suppl 3)
MissingFormLabel
- 10
Jasmin J F, Lucas M, Cernacek P, Dupuis J.
Effectiveness of a nonselective ET(A/B) and a selective ET(A) antagonist in rats with
monocrotaline-induced pulmonary hypertension.
Circulation.
2001;
103
314-318
MissingFormLabel
- 11
Hirata Y, Emori T, Eguchi S. et al .
Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine
endothelial cells.
J Clin Invest.
1993;
91
1367-1373
MissingFormLabel
- 12
Filep J G, Herman F, Battistini B, Chabrier P E, Braquet P, Sirois P.
Antiaggregatory and hypotensive effects of endothelin-1 in beagle dogs: role for prostacyclin.
J Cardiovasc Pharmacol.
1991;
17
S216-218
(Suppl 7)
MissingFormLabel
- 13
Giaid A, Saleh D.
Reduced expression of endothelial nitric oxide synthase in the lungs of patients with
pulmonary hypertension.
N Engl J Med.
1995;
333
214-221
MissingFormLabel
- 14
Tuder R M, Cool C D, Geraci M W. et al .
Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary
hypertension.
Am J Respir Crit Care Med.
1999;
159
1925-1932
MissingFormLabel
- 15
Giaid A, Yanagisawa M, Langleben D. et al .
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.
N Engl J Med.
1993;
328
1732-1739
MissingFormLabel
- 16
Dupuis J, Cernacek P, Tardif J C. et al .
Reduced pulmonary clearance of endothelin-1 in pulmonary hypertension.
Am Heart J.
1998;
135
614-620
MissingFormLabel
- 17
Rubens C, Ewert R, Halank M. et al .
Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of
primary pulmonary hypertension.
Chest.
2001;
120
1562-1569
MissingFormLabel
- 18
Galie N, Manes A, Branzi A.
The endothelin system in pulmonary arterial hypertension.
Cardiovasc Res.
2004;
61
227-237
MissingFormLabel
- 19
Bauer M, Wilkens H, Langer F, Schneider S O, Lausberg H, Schafers H J.
Selective upregulation of endothelin B receptor gene expression in severe pulmonary
hypertension.
Circulation.
2002;
105
1034-1036
MissingFormLabel
- 20
Clozel M, Breu V, Gray G A. et al .
Pharmacological characterization of bosentan, a new potent orally active nonpeptide
endothelin receptor antagonist.
J Pharmacol Exp Ther.
1994;
270
228-235
MissingFormLabel
- 21
Teerlink J R, Carteaux J P, Sprecher U, Loffler B M, Clozel M, Clozel J P.
Role of endogenous endothelin in normal hemodynamic status of anesthetized dogs.
Am J Physiol.
1995;
268
H432-440
MissingFormLabel
- 22
Weber C, Schmitt R, Birnboeck H. et al .
Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan
in healthy human subjects.
Clin Pharmacol Ther.
1996;
60
124-137
MissingFormLabel
- 23
Clozel M.
Effects of bosentan on cellular processes involved in pulmonary arterial hypertension:
do they explain the long-term benefit?.
Ann Med.
2003;
35
605-613
MissingFormLabel
- 24
Chen S J, Chen Y F, Meng Q C, Durand J, Dicarlo V S, Oparil S.
Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension
in rats.
J Appl Physiol.
1995;
79
2122-2131
MissingFormLabel
- 25
Kim H, Yung G L, Marsh J J. et al .
Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic
pulmonary hypertension.
Eur Respir J.
2000;
15
640-648
MissingFormLabel
- 26
Dingemanse J, van Giersbergen P L.
Clinical pharmacology of bosentan, a dual endothelin receptor antagonist.
Clin Pharmacokinet.
2004;
43
1089-1115
MissingFormLabel
- 27
Weber C, Gasser R, Hopfgartner G.
Absorption, excretion, and metabolism of the endothelin receptor antagonist bosentan
in healthy male subjects.
Drug Metab Dispos.
1999;
27
810-815
MissingFormLabel
- 28
van Giersbergen P L, Halabi A, Dingemanse J.
Single- and multiple-dose pharmacokinetics of bosentan and its interaction with ketoconazole.
Br J Clin Pharmacol.
2002;
53
589-595
MissingFormLabel
- 29
Cohen H, Chahine C, Hui A, Mukherji R.
Bosentan therapy for pulmonary arterial hypertension.
Am J Health Syst Pharm.
2004;
61
1107-1119
MissingFormLabel
- 30 Fachinformation zu Tracleer®,. Actelion Ltd. (London) 2004
MissingFormLabel
- 31
Packer M, McMurray J, Massie B M. et al .
Clinical effects of endothelin receptor antagonism with bosentan in patients with
severe chronic heart failure: results of a pilot study.
J Card Fail.
2005;
11
12-20
MissingFormLabel
- 32
Rubin L J, Badesch D B, Barst R J. et al .
Bosentan therapy for pulmonary arterial hypertension.
N Engl J Med.
2002;
346
896-903
MissingFormLabel
- 33
Fattinger K, Funk C, Pantze M. et al .
The endothelin antagonist bosentan inhibits the canalicular bile salt export pump:
a potential mechanism for hepatic adverse reactions.
Clin Pharmacol Ther.
2001;
69
223-231
MissingFormLabel
- 34
Weiss B M, Zemp L, Seifert B, Hess O M.
Outcome of pulmonary vascular disease in pregnancy: a systematic overview from 1978
through 1996.
J Am Coll Cardiol.
1998;
31
1650-1657
MissingFormLabel
- 35
Channick R, Simonneau G, Sitbon O. et al .
Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary
hypertension: a placebo-controlled study.
Lancet.
2001;
358
1119-1123
MissingFormLabel
- 36
Liu C, Cheng J.
Endothelin receptor antagonists for pulmonary arterial hypertension.
Cochrane Database Syst Rev.
2005;
1
CD004434
MissingFormLabel
- 37
Miyamoto S, Nagaya N, Satoh T. et al .
Clinical correlates and prognostic significance of six-minute walk test in patients
with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing.
Am J Respir Crit Care Med.
2000;
161
487-492
MissingFormLabel
- 38
McLaughlin V V, Sitbon O, Badesch D B. et al .
Survival with first-line bosentan in patients with primary pulmonary hypertension.
Eur Respir J.
2005;
25
244-249
MissingFormLabel
- 39
Galie N, Hinderliter A L, Torbicki A. et al .
Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and
doppler measures in patients with pulmonary arterial hypertension.
J Am Coll Cardiol.
2003;
41
1380-1386
MissingFormLabel
- 40
Hoeper M M, Taha N, Bekjarova A, Gatzke R, Spiekerkoetter E.
Bosentan treatment in patients with primary pulmonary hypertension receiving nonparenteral
prostanoids.
Eur Respir J.
2003;
22
330-334
MissingFormLabel
- 41
Humbert M, Barst R J, Robbins I M. et al .
Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2.
Eur Respir J.
2004;
24
353-359
MissingFormLabel
- 42
Ivy D D, Doran A, Claussen L, Bingaman D, Yetman A.
Weaning and discontinuation of epoprostenol in children with idiopathic pulmonary
arterial hypertension receiving concomitant bosentan.
Am J Cardiol.
2004;
93
943-946
MissingFormLabel
- 43
Wilkins M R, Paul G A, Strange J W. et al .
Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH)
study.
Am J Respir Crit Care Med.
2005;
171
1292-1297
MissingFormLabel
- 44
Hoeper M M, Faulenbach C, Golpon H, Winkler J, Welte T, Niedermeyer J.
Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial
hypertension.
Eur Respir J.
2004;
24
1007-1010
MissingFormLabel
- 45
Olschewski H, Ghofrani A, Enke B. et al .
Therapy of pulmonary arterial hypertension.
Internist (Berl).
2005;
46
341-349
MissingFormLabel
- 46
Matthes J, Mathen F, Herzig S, Wassermann K.
Therapie der schweren pulmonalen Hypertonie mit Prostazyklin und Iloprost.
Dtsch Med Wochenschr.
2001;
126
631-637
MissingFormLabel
Dr. Jan Matthes
Institut für Pharmakologie, Universität zu Köln
Gleueler Straße 24
50931 Köln
Telefon: 0221/4785674
Fax: 0221/4785022
eMail: jan.matthes@uni-koeln.de