Injectable Atypical Antipsychotics for Agitation in Borderline Personality Disorder

Agitation is relatively common among Borderline Personality Disorder (BPD) patients in Psychiatric Emergency Services (PES).New injectable atypical antipsychotics are indicated for treatment in agitated psychotic or maniac patients but not for agitated BDP patients. Twenty agitated BPD patients were treated with intramuscular atypical antipsychotics (olanzapine or ziprasidone). Results suggest intramuscular atypical antipsychotics may be effective, fast and safe for treating acute BPD patients.

References

• 1 Allen M H. Managing the agitated psychotic patient: a reappraisal of the evidence.  J Clin Psychiatry. 2000;  61 (Suppl 14) 11 - 20
• 2 American Psychiatric Association Practice Guidelines: Practice guideline for the treatment of patients with borderline personality d isorder. American Psychiatric Association.  Am J Psychiatry. 2001;  158 (Suppl 10) 1-52
• 3 Currier G W. Atypical antipsychotic medications in the psychiatric emergency service.  J Clin Psychiatry. 2000;  61 (Suppl 14) 21-26
• 4 Currier G W, Allen M H, Bunney E B, Daniel D G, Francis A, Jagoda A, Zimbroff D. Standard therapies for acute agitation.  J Emerg Med. 2004;  27 (Suppl 4) S9-12
• 5 Forster A, Gardaz J P, Suter P M, Gemperle M. Respiratory depression by midazolam and diazepam.  Anesthesiology. 1980;  53 494-497
• 6 Grootens K P, Verkes R J. Emerging evidence for the use of atypical antipsychotics in borderline personality disorder.  Pharmacopsychiatry. 2005;  38 20-23
• 7 Pascual J C, Madre M, Puigdemont D. et al .A naturalistic study: 100 consecutive episodes of acute agitation in a psychiatric emergency department. Act Esp Psiquiatr 2005: in press
• 8 Pascual J C, Oller S, Soler J. et al . Ziprasidone in the acute treatment of borderline personality disorder in psychiatric emergency services.  J Clin Psychiatry. 2004;  65 1281-1282
• 9 Soler J, Pascual J C, Campins J, Barrachina J, Puigdemont D, Alvarez E, Pérez V. Double-blind, placebo-controlled study of borderline personality disorder: Olanzapine plus dialectical behavior therapy.  Am J Psychiatry. 2005;  162 1221-1224