Triterpenoids and Sesquiterpenes from Mulgedium tataricum

Abstract

The chemical investigation of Mulgedium tataricum afforded six new compounds which were identified as lanost-9(11),23Z(24)-diene-3β,25-diol (1), lanost-9(11),25-diene-3β,24β-diol (2), ursane-20-ene-3β,22α-diol (3), 4E,10E-3β,11β-dihydroxygermacra-4(5),10(1)-dien-12,6α-olide (4), 4E-1β-hydroperoxy-3β,11β-dihydroxygermacra-4(5),10(14)-dien-12,6α-olide (5) and lactucin-8-O-p-methoxyphenyl acetate (6) by using a combination of MS and NMR techniques. Compound 6 exhibited significant cytotoxicity against cultured human hepatoma cells (SMMC-7721) and human acute promyelocytic leukemia cells (HL60). The antibacterial activity study indicated that 1 and 2 strongly inhibited the growth of Escherichia coli.

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