A New Adjacent Bis-Tetrahydrofuran Annonaceous Acetogenin from the Seeds of Uvaria chamae

Abstract

A novel acetogenin, joolanin (1), along with eight known acetogenins, squamocin (2), desacetyluvaricin (3), chamuvarinin (4), tripoxyrollin (5), diepoxyrollin (6), dieporeticanin-1 (7), dieporeticanin-2 (8) and dieporeticenin (9) were isolated from the seeds of Uvaria chamae (Annonaceae). Compound 1, the first adjacent bis-tetrahydrofuranic ring acetogenin bearing a ketone group at C-5, shows significant cytotoxicity towards the KB 3 - 1 cell line (IC₅₀ = 0.4 nM).

References

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