Abstract
The base-promoted cyclization of internal N-propargylmalonamides in the presence of carbonate bases at room temperature or at 80 °C affords highly substituted 3-pyrrolin-2-ones in good yields.
Key words
cyclizations - 3-pyrrolin-2-ones - lactams - propargylamines - palladium
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31 Carried out using piperidine in place of Et3N, with 0.04 equiv of Cul.
