Abstract
The synthesis of l -2-amino-8-oxodecanoic acid (Aoda) is described. This is a rare amino acid component of apicidins, a family of new cyclic tetrapeptides, inhibitors of histone deacetylase. Aoda was synthesised in seven steps from l -glutamic acid, along with some derivatives.
Key words
amino acid - Aoda - apicidins - histone deacetylase - inhibitors
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