Traceless Solid-Phase Synthesis of 3-Substituted Isoxazoles and 3-Substituted 5-Iodoisoxazolines Using Polystyrene-Supported Vinyl Selenide

Shou-Ri Sheng; Qin Xin; Xiao-Ling Liu; Wu-Kang Sun; Rui Guo; Xian Huang

doi:10.1055/s-2006-942436

PAPER

Traceless Solid-Phase Synthesis of 3-Substituted Isoxazoles and 3-Substituted 5-Iodoisoxazolines Using Polystyrene-Supported Vinyl Selenide

Shou-Ri Sheng*^a, Qin Xin^a, Xiao-Ling Liu^a, Wu-Kang Sun^a, Rui Guo^a, Xian Huang^a,b
^a Institutes of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, 330027, P. R. of China
Fax: +86(791)8517500; e-Mail: shengsr@jxnu.edu.cn;
^b Department of Chemistry, Zhejiang University, Hangzhou, 310028, P. R. of China

Abstract

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Abstract

A novel facile procedure for the traceless solid-phase synthesis of 3-substituted isoxazoles and 3-substituted 5-iodoisoxazolines in good yields and with excellent purities using polymer-supported vinyl selenide is described. The polymeric reagent can be regenerated and reused as an environmentally benign reagent.

Key words

solid-phase organic synthesis - polymer-supported vinyl selenide - isoxazole - isoxazoline

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