Abstract
An efficient procedure was established to synthesize a thymidine analogue bearing an acylsilane function at the 5′-position, starting from thymidine in four steps and 58% overall yield. This compound proved to be a valuable intermediate for the synthesis of various nucleoside analogues with a one-carbon chain elongation at the 5′-position and a useful compound towards the construction of modified oligonucleotides.
Key words
acylsilanes - thymidine - nucleoside analogues - photo-Brook rearrangement - oxidation
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