Abstract
Montiporyne E, a novel diacetylenic lactam isolated from the stony coral Montipora sp. , was shown to exhibit cytotoxicity against certain solid tumor cells. Construction of a suitably functionalized α,β-unsaturated lactam for palladium-catalyzed couplings was realized via a Beckmann rearrangement. Subsequent Sonagoshira coupling with a known alkyne chain efficiently afforded the alleged structure of the natural product.
Key words
synthesis - Beckmann - lactams - coupling reactions - alkynes
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