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Synthesis 2006(14): 2440-2443
DOI: 10.1055/s-2006-942458
DOI: 10.1055/s-2006-942458
PSP
© Georg Thieme Verlag Stuttgart · New York
Simple and Efficient Multigram Scale Synthesis of 1-Aminocyclopent-3-ene-1-carboxylic Acid
Further Information
Received
16 March 2006
Publication Date:
07 July 2006 (online)
Publication History
Publication Date:
07 July 2006 (online)
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Abstract
A very simple and inexpensive synthesis of the valuable intermediate 1-aminocyclopent-3-ene-1-carboxylic acid on a multigram scale and with a high overall yield (80%) is reported. The efficiency of the procedure relies on the ready accessibility and high reactivity of the glycine equivalent used as the starting material.
Key words
allylations - amino acids - heterocycles - metathesis - ring closure
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