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DOI: 10.1055/s-2006-942507
Five- and Six-Membered Nickelacyclic Carboxylates as Reagents for the Facile Synthesis of δ-Ketocarboxylic Acids, Isocoumarins, and 1,3-Dicarbonyl Derivatives of Benzoic Acid
Publikationsverlauf
Publikationsdatum:
19. Juli 2006 (online)

Abstract
The nickelacyclic carboxylates A and B reacted with α-halo ketones to form α,β-unsaturated δ-ketocarboxylic acids which were easily converted into pyranones or isocoumarins. In addition, reaction of the nickelacyclic acyl derivative C with α-halo ketones resulted in the formation of substituted 1,3-dicarbonyl compounds with a benzoic acid substituent in the 1-position. In these reactions, many functional groups were tolerated.
Key words
cross coupling - metallacycles - organometallic reagents - nickel - heterocycles
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