Three-Component Synthesis of Homoallylic Amines Promoted by Carboxylic Acids

Gui-long Li; Gang Zhao

doi:10.1055/s-2006-942548

PAPER

Three-Component Synthesis of Homoallylic Amines Promoted by Carboxylic Acids

Gui-long Li, Gang Zhao*
Laboratory of Modern Synthetic Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Feng Lin Lu, Shanghai 200032, P. R. of China
Fax: +86(21)64166128; e-Mail: Zhaog @mail.sioc.ac.cn;

Abstract

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Abstract

A highly selective, three-component reaction promoted by carboxylic acids for the synthesis of homoallylic amines has been developed. By using maleic acid or trifluoroacetic acid as a promoter, the reaction between a variety of aldehydes, aromatic amines, and allyltin reagents proceeds smoothly to afford the corresponding homoallylic amines in moderate to quantitative yields under mild conditions.

Key words

allylations - carboxylic acids - imines - multicomponent reactions - tin

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