Therapeutische Hypothermie nach Asphyxie aus neonatologischer Sicht

Kernaussagen

Die neuroprotektive Wirkung der Hypothermie wurde in zahlreichen Tierversuchen untersucht und bestätigt.

Die 3 klinischen randomisierten Studien bestätigten den neuroprotektiven Effekt, allerdings in unterschiedlichem Ausmaß für verschiedene Patientengruppen. Aufgrund einer kontroversen Sicht ist noch nicht klar, unter welcher Datenlage und unter welchen lokalen Bedingungen die Hypothermie als Standardtherapie für asphyktische Neugeborene mit HIE gelten kann.

In den bisherigen klinischen Studien traten keine klinisch relevanten Nebenwirkungen auf.

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