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Pharmacopsychiatry 2006; 39(3): 114
DOI: 10.1055/s-2006-946609
DOI: 10.1055/s-2006-946609
Letter
© Georg Thieme Verlag KG Stuttgart · New York
Dramatic Remission of Treatment-resistant Depression after the Cessation of Tricyclic Antidepressants
A Case ReportFurther Information
Publication History
Received: 15.11.2005
Accepted: 12.1.2006
Publication Date:
23 May 2006 (online)
![](https://www.thieme-connect.de/media/pharmaco/200603/lookinside/thumbnails/10.1055-s-2006-946609-1.jpg)
Recently, tricyclic antidepressants (TCAs) have been used mainly for treatment-resistant depression (TRD) because of their significant side effects [5]. We report a patient whose prolonged depressive symptoms dramatically improved after the cessation of TCAs. TCAs may cause deterioration of depressive symptoms due to their neurotoxicity.
References
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- 2 Gerner P, Mujtaba M, Khan M, Sudoh Y, Vlassalov K, Anthony D C. et al . N-phenylethyl amitriptyline in rat sciatic nerve blockade. Anesthesiology. 2002; 96 1435-1442
- 3 Müller M J, Himmerich H, Kienzle B, Szegedi A. Differentiating moderate and severe depression using the Montgomery-Åsberg depression rating scale (MADRS). J Affect Disord. 2003; 77 255-260
- 4 Perry P J, Pfohl B M. The relationship between antidepressant response and tricyclic antidepressant plasma concentrations. A retrospective analysis of the literature using logistic regression analysis. Clin Pharmacokinet. 1987; 13 381-392
- 5 Thase M E. Therapeutic alternatives for difficult-to-treat depression: a narrative review of the state of the evidence. CNS Spectr. 2004; 9 808 - 816, 818-821
Keizo Yoshida, M.D., Ph. D.
Department of Psychiatry
Nagoya University Graduate School of Medicine
65 Tsurumai-cho
Showa-ku
Nagoya
Aichi 466-8550
Japan
Phone: +81 52 744 2283
Fax: +81 52 744 2293
Email: cxw01076@nifty.com