Endoscopy 2006; 38: 17-21
DOI: 10.1055/s-2006-946645
Invited papers
Esophageal tumors
© Georg Thieme Verlag KG Stuttgart · New York

State of the art lecture: EUS for esophageal tumors

W. A. Marsman1 , P. Fockens1
  • 1Dept. of Experim. Hepatology, Academic Medical Center, Amsterdam
Further Information

Publication History

Publication Date:
26 June 2006 (online)

Introduction

Treatment and outcome of patients with esophageal cancer is stage dependent. Since its introduction in the early 1980 s, EUS has played a central role in the staging of esophageal cancer. Adequate staging of esophageal cancer is important in the initial triage of patients to receive immediate surgery, neoadjuvant therapy or palliative treatment only. Also in patients with early cancer, EUS can be used to evaluate the possibility of endoscopic mucosal resection. EUS remains superior in T- and N-staging of esophageal cancer compared to other imaging modalities such as CT, PET and MRI. New developments will hopefully further improve the staging of early lesions, stenotic lesions and the diagnostics of lymph node metastases. Nowadays many patients are being treated with neoadjuvant chemo-radiotherapy. EUS could also play a role in the assessment of these therapies and to give direction towards further management.

References

  • 1 Murata Y, Napoleon B, Odegaard S. High-frequency endoscopic ultrasonography in the evaluation of superficial esophageal cancer.  Endoscopy. 2003;  35 429-435
  • 2 Van Dam J, Rice T W, Catalano M F, Kirby T, Sivak Jr M . High-grade malignant stricture is predictive of esophageal tumor stage. Risks of endosonographic evaluation.  Cancer. 1993;  71 2910-2917
  • 3 Mallery S, Van Dam J. Increased rate of complete EUS staging of patients with esophageal cancer using the nonoptical, wire-guided echoendoscope.  Gastrointest Endosc. 1999;  50 53-57
  • 4 Gines A, Wiersema M J, Clain J E, Pochron N L, Rajan E, Levy M J. Prospective study of a Trucut needle for performing EUS-guided biopsy with EUS-guided FNA rescue.  Gastrointest Endosc. 2005;  62 597-601
  • 5 Enzinger P Z, Page D L, Fleming I D. et al .AJCC Cancer Staging Manual (ed 6). New York; New York Springer 200
  • 6 van Westreenen H L, Heeren P A, van Dullemen H M, van der Jagt E J, Jager P L, Groen H, Plukker J T. Positron emission tomography with F-18-fluorodeoxyglucose in a combined staging strategy of esophageal cancer prevents unnecessary surgical explorations.  J Gastrointest Surg. 2005;  9 54-61
  • 7 Ide H, Nakamura T, Hayashi K, Endo T, Kobayashi A, Eguchi R, Hanyu F. Esophageal squamous cell carcinoma: pathology and prognosis.  World J Surg. 1994;  18 321-330
  • 8 Rosch T. Endosonographic staging of esophageal cancer: a review of literature results.  Gastrointest Endosc Clin N Am. 1995;  5 537-547
  • 9 Berger A C, Scott W J. Noninvasive staging of esophageal carcinoma.  J Surg Res. 2004;  117 127-133
  • 10 Pfau P R, Ginsberg G G, Lew R J, Brensinger C M, Kochman M L. EUS predictors of long-term survival in esophageal carcinoma.  Gastrointest Endosc. 2001;  53 463-469
  • 11 Eloubeidi M A, Desmond R, Arguedas M R, Reed C E, Wilcox C M. Prognostic factors for the survival of patients with esophageal carcinoma in the U.S.: the importance of tumor length and lymph node status.  Cancer. 2002;  95 1434-1443
  • 12 Tio T L, Coene P P, Hartog Jager F C, Tytgat G N. Preoperative TNM classification of esophageal carcinoma by endosonography.  Hepatogastroenterology. 1990;  37 376-381
  • 13 Kelly S, Harris K M, Berry E, Hutton J, Roderick P, Cullingworth J, Gathercole L, Smith M A. A systematic review of the staging performance of endoscopic ultrasound in gastro-oesophageal carcinoma.  Gut. 2001;  49 534-539
  • 14 Chen V K, Eloubeidi M A. Endoscopic ultrasound-guided fine needle aspiration is superior to lymph node echofeatures: a prospective evaluation of mediastinal and peri-intestinal lymphadenopathy.  Am J Gastroenterol. 2004;  99 628-633
  • 15 Eloubeidi M A, Mason A C, Desmond R A, El Serag H B. Temporal trends (1973 - 1997) in survival of patients with esophageal adenocarcinoma in the United States: a glimmer of hope?.  Am J Gastroenterol. 2003;  98 1627-1633
  • 16 Marsman W A, van Wissen M, Bergman J J, van Lanschot J J, Obertop H, Tytgat G N, Fockens P. Outcome of patients with esophageal carcinoma and suspicious celiac lymph nodes as determined by endoscopic ultrasonography.  Endoscopy. 2004;  36 961-965
  • 17 Eloubeidi M A, Wallace M B, Reed C E, Hadzijahic N, Lewin D N, Van Velse A, Leveen M B, Etemad B, Matsuda K, Patel R S, Hawes R H, Hoffman B J. The utility of EUS and EUS-guided fine needle aspiration in detecting celiac lymph node metastasis in patients with esophageal cancer: a single-center experience.  Gastrointest Endosc. 2001;  54 714-719
  • 18 Vazquez-Sequeiros E, Wiersema M J, Clain J E, Norton I D, Levy M J, Romero Y, Salomao D, Dierkhising R, Zinsmeister A R. Impact of lymph node staging on therapy of esophageal carcinoma.  Gastroenterology. 2003;  125 1626-1635
  • 19 Prasad P, Schmulewitz N, Patel A, Varadarajulu S, Wildi S M, Roberts S, Tutuian R, King P, Hawes R H, Hoffman B J, Wallace M B. Detection of occult liver metastases during EUS for staging of malignancies.  Gastrointest Endosc. 2004;  59 49-53
  • 20 Flamen P, Lerut A, Van Cutsem E, Cambier J P, Maes A, De Wever W, Peeters M, De Leyn P, Van Raemdonck D, Mortelmans L. The utility of positron emission tomography for the diagnosis and staging of recurrent esophageal cancer.  J Thorac Cardiovasc Surg. 2000;  120 1085-1092
  • 21 Isenberg G, Chak A, Canto M I, Levitan N, Clayman J, Pollack B J, Sivak Jr M . Endoscopic ultrasound in restaging of esophageal cancer after neoadjuvant chemoradiation.  Gastrointest Endosc. 1998;  48 158-163
  • 22 Kalha I, Kaw M, Fukami N, Patel M, Singh S, Gagneja H, Cohen D, Morris J. The accuracy of endoscopic ultrasound for restaging esophageal carcinoma after chemoradiation therapy.  Cancer. 2004;  101 940-947
  • 23 Willis J, Cooper G S, Isenberg G, Sivak Jr M , Levitan N, Clayman J, Chak A. Correlation of EUS measurement with pathologic assessment of neoadjuvant therapy response in esophageal carcinoma.  Gastrointest Endosc. 2002;  55 655-661
  • 24 Westerterp M, van Westreenen H L, Reitsma J B, Hoekstra O S, Stoker J, Fockens P, Jager P L, Eck-Smit B L, Plukker J T, van Lanschot J J, Sloof G W. Esophageal cancer: CT, endoscopic US, and FDG PET for assessment of response to neoadjuvant therapy - systematic review.  Radiology. 2005;  236 841-851
  • 25 Harewood G C, Kumar K S. Assessment of clinical impact of endoscopic ultrasound on esophageal cancer.  J Gastroenterol Hepatol. 2004;  19 433-439
  • 26 Preston S R, Clark G W, Martin I G, Ling H M, Harris K M. Effect of endoscopic ultrasonography on the management of 100 consecutive patients with oesophageal and junctional carcinoma.  Br J Surg. 2003;  90 1220-1224
  • 27 Ainsworth A P, Mortensen M B, Durup J, Wamberg P A. Clinical impact of endoscopic ultrasonography at a county hospital.  Endoscopy. 2002;  34 447-450
  • 28 Nickl N J, Bhutani M S, Catalano M, Hoffman B, Hawes R, Chak A, Roubein L D, Kimmey M, Johnson M, Affronti J, Canto M, Sivak M, Boyce H W, Lightdale C J, Stevens P, Schmitt C. Clinical implications of endoscopic ultrasound: the American Endosonography Club Study.  Gastrointest Endosc. 1996;  44 371-377
  • 29 Fockens P, Kisman K, Merkus M P, van Lanschot J J, Obertop H, Tytgat G N. The prognosis of esophageal carcinoma staged irresectable (T4) by endosonography.  J Am Coll Surg. 1998;  186 17-23
  • 30 Hulscher J B, van Sandick J W, de Boer A G, Wijnhoven B P, Tijssen J G, Fockens P, Stalmeier P F, ten Kate F J, van Dekken H, Obertop H, Tilanus H W, van Lanschot J J. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus.  N Engl J Med. 2002;  347 1662-1669

Dr. med. W. A. Marsman

Dept. of Experim. Hepatology

Academic Medical Center

Meibergdreef 9

1105 AZ Amsterdam

The Netherlands