The advantage of endoscopic ultrasonography (EUS) is its high resolution and capability of local observation [1]
[2]. It is one of the most accurate diagnostic methods, particularly for the pancreatobiliary region, where various advanced imaging diagnostic methods available today, such as CT and MRI [3]
[4]. Since EUS is most useful for diagnosing a small lesion, its usage for early diagnosis of pancreatobiliary cancer has being anticipated.
Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA) was developed to enhance the diagnostic capability of EUS by providing additional pathological findings [5]
[6]
[7].
However, it is not clearly known yet whether EUS is actually useful for the diagnosis of small pancreatic tumor, whether EUS-FNA is indispensable when a small tumor is detected. It is also necessary to understand for what size of tumor EUS-FNA can be used, and if there is no risk of complication or not. This time, I introduce the present state of diagnosing small pancreatic tumors, the application of EUS-FNA, and the discussion of the points to be solved.
References
1
Rosch T, Braig C, Gain T. et al .
Staging of pancreatic and ampullary carcinoma by endoscopic ultrasonography: comparison with conventional ultrasonography, computed tomography, and angiography.
J Gastroenterol.
1992;
102
188-199
5
Vilmann P, Jacobsen G K, Henriksen F W. et al .
Endoscopic ultrasonography with guided fine needle aspiration biopsy in pancreatic disease.
Gastrointest Endosc.
1992;
38
172-173
6
Tio T L, Sie L H, Tygat G N.
Endosonography and cytology in diagnosing and staging pancreatic body and tail carcinoma. Preliminary results of endosonographic guided puncture.
Dig Dis Sci.
1993;
38
59-64
7
Binmoeller K F, Jabusch H C, Seifert H. et al .
Endosonography-guided fine-needle biopsy of indurated pancreatic lesions using an automated biopsy device.
Endoscopy.
1997;
29
384-388
8
Shimizu Y, Yasui K, Matueda K. et al .
Small carcinoma of the pancreas is curable: new computed tomography findings, pathological study and postoperative results from a single institute.
J Gastroenterol Hepatol.
2005;
20
1591-1594
10
Furukawa T, Tsukamoto Y, Naitoh Y. et al .
Differential diagnosis of pancreatic diseases with an intraductal ultrasound system.
Gastrointest Endosc.
1994;
40
213-219
12
Koito K, Namieno T, Nagakawa T. et al .
Inflammatory pancreatic masses: differentiation from ductal carcinomas with contrast-enhanced sonography using carbon dioxide microbubbles.
Am J Radiology.
1997;
169
1263-1267
13
Takahashi K, Yamao K, Okubo K. et al .
Differential diagnosis of pancreatic cancer and focal pancreatitis by using EUS-guided FNA.
Gastrointst Endosc.
2005;
61
76-79
14
Itoi T, Itokawa F, Sofuni A. et al .
Pancture of solid pancreatic tumors guided by endoscopic ultrasonography: a pilot study series comparing Trucut and 19-gauge and 22-gauge aspiration needles.
Endoscopy.
2005;
37
362-366
15
Ryozawa S, Kitoh H, Gondo T. et al .
Usefulness of endoscopic ultrasound-guided fine-needle aspiration biopsy for the diagnosis of pancreatic cancer.
J Gastroenterol.
2005;
40
907-911
16
Obara T, Maguchi H, Saitoh Y. et al .
Intraductal papillary neoplasms of the pancreas: diagnosis by Endoscopic Pancreatic Biopsy.
Endoscopy.
1993;
25
290-293
17
Yamao K, Sawaki A, Mizuno N. et al .
Endoscopic ultrasound-guided fine-needle aspiration biopsy(EUS-FNAB): past, present, and future.
J Gastroenterol.
2005;
40
1013-1023
19
Hirooka Y, Goto H, Itoh A. et al .
Case of intraductal papillary mucinous tumor in which endosonography-guided fine-needle aspiration biopsy caused dissemination.
J Gastroenterol Hepatol.
2003;
18
1323-1324
21
Paquin S C, Gariepy G, Lepanto L. et al .
A first report of tumor seeding because of EUS-guided FNA of a pancreatic adenocarcinoma.
Gastrointest Endosc.
2005;
61
610-611
22
Frossard J L, Amouyal P, Amouyal G. et al .
Performance of endosonography-guided fine needle aspiration and biopsy in the diagnosis of pancreatic cystic lesions.
Am J Gastroenterol.
2003;
98
1516-1524
23
Hernandez L V, Mishra G, Forsmark C. et al .
Role of endoscopic ultrasound(EUS) and EUS-guided fine needle aspiration in the diagnosis and treatment of cystic lesions of the pancreas.
Pancreas.
2002;
25
222-228