Planta Med 2006; 72(10): 951-954
DOI: 10.1055/s-2006-947178
Letter
© Georg Thieme Verlag KG Stuttgart · New York

A New Triterpene and Anti-Hepatitis B Virus Active Compounds from Alisma orientalis

Zhi-Yong Jiang1 , Xue-Mei Zhang1 , Feng-Xue Zhang2 , Ni Liu2 , Fang Zhao2 , Jun Zhou1 , 3 , Ji-Jun Chen1 , 3
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, Yunnan, P. R. China
  • 2Institute of Tropical Medicine Sciences, Guangzhou University of Chinese Traditional Medicines, Guangzhou, P. R. China
  • 3The Joint-Laboratory of anti-Viral Natural Medicines, Kunming Branch, the Chinese Academy of Sciences, Kunming, Yunnan, P. R. China
Further Information

Publication History

Received: November 20, 2005

Accepted. May 23, 2006

Publication Date:
20 July 2006 (online)

Abstract

A new triterpenoid named alisol O (1) was isolated from the rhizomes of Alisma orientalis, together with six known compounds: alisol A 24-acetate (2), 25-anhydroalisol A (3), 13β,17β-epoxyalisol A (4), alisol B 23-acetate (5), alisol F (6), and alisol F 24-acetate (7). Based on 1D and 2D-NMR data (HMQC, HMBC, COSY, ROESY), the structure of the new compound was deduced to be 11-dehydroxy-12-dehydroalisol F-24-acetate (1). Compounds 2 - 7 exhibited inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC50 values of 2.3, 11.0, 15.4, 14.3, 0.6 and 7.7 μM, and on HBV e antigen (HBeAg) secretion with IC50 values of 498.1, 17.6, 41.0, 19.9, 8.5 and 5.1 μM, respectively.

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Prof. Dr. Ji-Jun Chen

State Key Laboratory of Phytochemistry and Plant Resources in West China

Kunming Institute of Botany

The Chinese Academy of Sciences

Kunming 650204

Yunnan

People’s Republic of China

Phone: +86-871-5223265

Fax: +86-871-5223265

Email: chenjj@mail.kib.ac.cn