Abstract
In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the 70 % EtOH extract of ”Pini Resina” showed 100 % preferential cytotoxicity at the concentration of 50 μg/mL. Further bioassay-guided fractionation and purification led to the isolation of 15 compounds including one new compound 7-oxo-13α-hydroxyabiet-8(14)-en-18-oic acid (1). Their structures were elucidated on the basis of spectroscopic analysis. Among the isolated compounds, methyl abieta-8,11,13-trien-18-oate (7) showed the most potent preferential cytotoxicity at 10 μg/mL under nutrient-deprived condition.
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Dr. Prof. Shigetoshi Kadota
Institute of Natural Medicine
University of Toyama
2630 Sugitani
Toyama 930-0194
Japan
Phone: +81-76-434-7625
Fax: +81-76-434-5059
Email: kadota@ms.toyama-mpu.ac.jp
