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Planta Med 2006; 72(10): 912-916
DOI: 10.1055/s-2006-947190
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Prenylated Xanthones as Potential Antiplasmodial Substances

Wilawan Mahabusarakam1 , Kunnika Kuaha2 , Prapon Wilairat3 , Walter C. Taylor4
  • 1Department of Chemistry, Prince of Songkla University, Hat Yai, Songkhla, Thailand
  • 2Department of Immunology, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand
  • 3Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
  • 4School of Chemistry, University of Sydney, Sydney, NSW, Australia
Further Information

Publication History

Received: February 22, 2006

Accepted: May 12, 2006

Publication Date:
10 August 2006 (online)

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Abstract

Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum. Mangostin itself showed moderate activity, but prenylated xanthones containing alkylamino functional groups exhibited quite potent antiplasmodial activity. Some structure-activity relationships are proposed.

Key words

Mangostin - G. mangostana - Guttiferae - prenylated xanthones - antiplasmodial - Plasmodium falciparum

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W. Mahabusarakam

Department of Chemistry

Prince of Songkla University

Hat Yai

Songkhla 90112

Thailand

Phone: +66-74-212-918

Fax: +66-74-212-918

Email: wilawan.m@psu.ac.th