Planta Med 2006; 72(13): 1241-1244
DOI: 10.1055/s-2006-947197
Letter
© Georg Thieme Verlag Stuttgart · New York

Growth Inhibitory Activity of Wood of Taxus yunnanensis and its Liquid Chromatography Fourier-Transform Mass Spectrometry Analysis

Jun-ya Ueda1 , Suresh Awale1 , Yasuhiro Tezuka1 , Eriko Shimamura2 , Kei-ichi Hirai2 , Takahiro Nobukawa2 , Akihiro Sato3 , Shigetoshi Kadota1
  • 1Institute of Natural Medicine, University of Toyama, Toyama, Japan
  • 2Kanazawa Medical University, Uchinada, Japan
  • 3Application Department, Division 2, JASCO International Co. Ltd., Hachioji, Japan
Further Information

Publication History

Received: April 28, 2006

Accepted: June 15, 2006

Publication Date:
10 August 2006 (online)

Abstract

The wood of Taxus yunnanensis (Taxaceae) showed growth inhibitory activities against human cancer cell lines, such as cervical HeLa adenocarcinoma. The morphological changes indicated that the cellular growth inhibitions were caused by apoptosis. To determine the active components, T. yunnanensis wood was analyzed by using a liquid chromatography-Fourier-transform MS (LC/FT-MS) technique. As a result, taxane-type diterpenes, such as 10-deacetylcephalomannine and 10-deacetyltaxol, were found to be present in amounts consistent with the growth inhibitory activity.

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Prof. Dr. Shigetoshi Kadota

Institute of Natural Medicine

University of Toyama

2630 Sugitani

Toyama 930-0194

Japan

Phone: +81-76-434-7625

Fax: +81-76-434-5059

Email: kadota@inm.u-toyama.ac.jp