Abstract
Adiponectin, which is encoded by the ADIPOQ gene, has been shown to modulate insulin sensitivity and glucose homeostasis. Plasma
adiponectin levels are decreased in type 2 diabetes and obesity. Genetic variations
within the ADIPOQ gene are associated with decreased adiponectin hormone levels. To analyze specific
single-nucleotide polymorphisms (SNPs) and their association with T2D, 365 German
subjects with T2D and 323 control subjects were screened. Three common SNPs - +45T>G
in exon 2, and 2 promoter variants SNPs -11391G>A and -11377C>G - were analyzed. We
found that the variant allele of SNP -11391G>A was significantly more frequent in
the diabetic patient group than in the control group (p=0.003). Carrying the haplotype
of SNP -11391A and SNP -11377C was associated with a 1.50-fold (p=0.03) increase in
diabetes risk. The combination of the A-C haplotype and the G-C haplotype was associated
with significantly elevated diabetes risk (OR=2.82 (95% CI: 1.35-5.91), p=0.006) after
correction for BMI and age. Our observations suggest that diploid combinations of
haplotype in the adiponectin gene promoter region contribute to the genetic risk of
T2D in individuals from a German Caucasian population.
Key words
Adiponectin -
ADIPOQ
- type 2 diabetes - haplotypes - promoter variants
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Correspondence
Dr. med. Peter Egbert Hermann SchwarzIII°
Medical Clinic·Carl Gustav Carus Medical School·Dresden University of Technology
Fetscherstrasse 74·01307 Dresden·Germany
Phone: +49/351/458 27 15
Fax: +49/351/458 87 03
Email: pschwarz@rcs.urz.tu-dresden.de
